International Journal of Emergency Medicine - Latest Articles

Improvement of refractory migraine headache by Propofol: Case series

Hassan Soleimanpour — 2012-05-15T00:00:00Z

Background: Several studies have been conducted on the managing of migraine headache and developing effective medications for decreasing the migraine-associated pain.Case presentationIntravenous propofol was prescribed (10 mg every 5 minutes) for 8 patients with intractable migraine headache visiting the Emergency Department. The average pain score, experienced by patients, was recorded using the Visual Analogue Scale, at the beginning of the treatment procedure and following the injection for 30 min (5-min intervals). The reported pain scores by patients decreased significantly (P=0.01) from 8.87+/-0.83 (CI: 8.17, 9.57) to 1.12+/-0.83 (CI: 0.43, 1.82), before and 30 min following the injectionDiscussionIt seems that in treatment of intractable migraine headache, GABAergic receptors, compared to the normal condition, are in lower activity status. Conclusion: Because of high tendency of propofol to GABAergic receptors, it probably changes this physiologic condition by activating the receptors, which results in a significant pain reduction.

Applications of minimally invasive cardiac output monitors

Jahan Porhomayon — 2012-04-24T00:00:00Z

Because of the increasing age of the population, critical care and emergency medicine physicians have seen an increased number of critically ill patients over the last decade. Moreover, the trend of hospital closures in the United States t imposes a burden of increased efficiency. Hence, the identification of devices that facilitate accurate but rapid assessments of hemodynamic parameters without the added burden of invasiveness becomes tantamount. The purpose of this review is to understand the applications and limitations of these new technologies.

Comparison of existing syncope rules and newly proposed Anatolian Syncope Rule to predict short-term serious outcomes after syncope in the Turkish population

Kamil Kayayurt — 2012-04-20T00:00:00Z

Background: We wished to compare the San Francisco Syncope Rule (SFSR), Evaluation of Guidelines in Syncope Study (EGSYS) and the Osservatorio Epidemiologico sulla Sincope nel Lazio (OESIL) risk scores and to assess their efficacy in recognising patients with syncope at high risk for short-term adverse events (death, the need for major therapeutic procedures, and early readmission to the hospital). We also wanted to test those variables to designate a local risk score, the Anatolian Syncope Rule (ASR). Methods: This prospective, cohort study was conducted at the emergency department of a tertiary care centre. Between December 1 2009 and December 31 2010, we prospectively collected data on patients of ages 18 and over who presented to the emergency department with syncope. Results: We enrolled 231 patients to the study. A univariate analysis found 23 variables that predicted syncope with adverse events. Dyspnoea, orthostatic hypotension, precipitating cause of syncope, age over 58 years, congestive heart failure, and electrocardiogram abnormality (termed DO-PACE) were found to predict short-term serious outcomes by logistic regression analysis and these were used to compose the ASR. The sensitivity of ASR, OESIL, EGSYS and SFSR for mortality were 100% (0.66 to 1.00); 90% (0.54 to 0.99), 80% (0.44 to 0.97) and 100% (0.66 to 1.00), respectively. The specificity of ASR, OESIL, EGSYS and SFSR for mortality were 78% (0.72 to 0.83); 76% (0.70 to 0.82); 80% (0.74 to 0.85) and 70% (0.63 to 0.76). The sensitivity of ASR, OESIL, EGSYS and SFSR for any adverse event were 97% (0.85 to 1.00); 70% (0.52 to 0.82); 56% (0.40 to 0.72) and 87% (0.72 to 0.95). The specificity of ASR, OESIL, EGSYS and SFSR for any adverse event were 72% (0.64 to 0.78); 82% (0.76 to 0.87); 84% (0.78 to 0.89); 78% (0.71 to 0.83), respectively. Conclusion: The newly proposed ASR appears to be highly sensitive for identifying patients at risk for short-term serious outcomes, with scores at least as good as those provided by existing diagnostic rules, and it is easier to perform at the bedside within the Turkish population. If prospectively validated, it may offer a tool to aid physicians' decision-making.

A Randomized Open-Label Trial On The Use Of Budesonide/Formoterol (Symbicort(R)) As An Alternative Reliever Medication For Mild To Moderate Asthmatic Attacks

Keng Sheng Chew — 2012-04-13T00:00:00Z

Background: Conventionally, a nebulized short-acting β-2 agonist like salbutamol is often used as the reliever in acute exacerbations of asthma. However, recent worldwide respiratory outbreaks discourage routine use of nebulization. Previous studies have shown that combined budesonide/formoterol (Symbicort®, AstraZeneca) is effective as both a maintenance and reliever anti-asthmatic medication. Methods: We performed a randomized, open-label study from March until August 2011 to compare the bronchodilatory effects of Symbicort® vs. nebulized salbutamol in acute exacerbation of mild to moderate asthmatic attack in an emergency department. Initial objective parameters measured include the oxygen saturation, peak expiratory flow rate (PEFR) and respiratory rate. During clinical reassessment, subjective parameters [i.e., Visual Analog Scale (VAS) and 5-point Likert scale of breathlessness] and the second reading of the objective parameters were measured. For the 5-point Likert scale, the patients were asked to describe their symptom relief as 1, much worse; 2, a little worse; 3, no change; 4, a little better; 5, much better. Results: Out of the total of 32 patients enrolled, 17 patients (53%) were randomized to receive nebulized salbutamol and 15 (47%) to receive Symbicort®. For both treatment arms, by using paired t- and Wilcoxon signed rank tests, it was shown that there were statistically significant improvements in oxygen saturation, PEFR and respiratory rate within the individual treatment groups (pre- vs. post-treatment). Comparing the effects of Symbicort® vs. nebulized salbutamol, the average improvement of oxygen saturation was 1% in both treatment arms (p = 0.464), PEFR 78.67 l/min vs. 89.41 l/min, respectively (p = 0.507), and respiratory rate 2/min vs. 2/min (p = 0.890). For subjective evaluation, all patients reported improvement in the VAS (average 2.45 cm vs. 2.20 cm), respectively (p = 0.765). All patients in both treatment arms reported either "a little better" or "much better" on the 5-point Likert scale, with none reporting "no change" or getting worse. Conclusion: This study suggests that there is no statistical difference between using Symbicort® vs. nebulized salbutamol as the reliever for the first 15 min post-intervention.

Subgaleal coiling of the proximal and distal components of a ventriculoperitoneal shunt.

Brian Kloss — 2012-03-16T00:00:00Z

Migration is a rare complication of venticuloperitoneal shunts and is thought to be associated with the "memory" of the plastic tubing and the windlass effect of neck flexion and extension. The purpose of this case report is to detail a very rare case of complete distal to proximal shunt migration.

Intraorbital foreign body projectile as a consideration for unilateral pupillary defect

Craig Czyz — 2012-03-05T00:00:00Z

Intraorbital foreign bodies are frequently the result of high-velocity injuries with varying clinical presentations. The resultant diagnosis, management, and outcome depend on the type of foreign body present, anatomical location, tissue disruption, and symptomatology. A patient who presented to the Emergency Department with a large intraorbital foreign body projectile that was not evident clinically, but found incidentally on computed tomography and subsequent plain films is reported. The emergency room physician needs to be aware of the differential diagnosis of a unilateral irregular pupil with or without visual acuity changes. The differential diagnosis for any trauma patient with an irregular pupil with significant visual loss must include intraorbital foreign body and associated injury to the optic nerve directly or via orbital compartment syndrome secondary to hemorrhage and/or edema. Patients with significantly decreased visual acuity may benefit from emergent surgical intervention. In patients with intact visual acuity, the patient must be monitored closely for any visual changes as this may require emergent surgical intervention.

The livelihoods of Haitian health-care providers after the January 2010 earthquake: a pilot study of the economic and quality-of-life impact of emergency relief

Rohini Haar — 2012-03-02T00:00:00Z

IntroductionAn effective international response to a disaster requires cooperation and coordination with the existing infrastructure. In some cases, however, international relief efforts can compete with the local work force and affect the balance of health-care systems already in place. This study seeks to evaluate the impact of the international humanitarian response to the 12 January 2010 earthquake on Haitian health-care providers (HHP). Methods: Fifty-nine HHPs were surveyed in August of 2010 using a modified World Health Organization Quality of Life-Brief questionnaire (WHOQoL-B) that included questions on respondents' workload before the earthquake, immediately after, and presently. The study population consisted of physicians, nurses, and technicians at public hospitals, non-governmental organization (NGO) clinics, and private offices in Port-au-Prince, Haiti. Results: Following the earthquake, public hospital and NGO providers reported a significant increase in their workload (15 of 17 and 22 of 26 respondents, respectively). Conversely, 12 of 16 private providers reported a significant decrease in workload (p < 0.0001). Although all groups reported working a similar number of hours prior to the earthquake (average 40 h/week), they reported working significantly different amounts following the earthquake. Public hospital and NGO providers averaged more than 50 h/week, and private providers averaged just over 33 h/week of employment (p < 0.001).Health-care providers working at public hospitals and NGOs, however, had significantly lower scores on the WHOQoL-B when answering questions about their environment (p < 0.001), and in open-ended responses often commented about the lack of potable water and poor access to toilets. Providers from all groups expressed dissatisfaction with the scope and quality of care provided at public hospitals and NGO clinics, as well as disappointment with the reduction in patient volume at private practices. Conclusions: The emergency medical response to the January 2010 earthquake in Haiti had the unintended consequence of poorly distributing work among HHPs. To create a robust health-care system in the long term while meeting short-term needs, humanitarian responses should seek to better integrate existing systems and involve local providers in the design and implementation of an emergency program.

Posterior reversible encephalopathy syndrome (PRES) and CT perfusion changes.

Vishnumurthy Shushrutha Hedna — 2012-02-29T00:00:00Z

Posterior reversible encephalopathy syndrome (PRES) can present with focal neurologic deficits, mimicking a stroke and can often represent a diagnostic challenge when presenting atypically. A high degree of suspicion is required in the clinical setting in order to yield the diagnosis. Cerebral CT perfusion (CTP) is utilized in many institutions as the first line in acute stroke imaging. CTP has proved to be a very sensitive measure of cerebral blood flow dynamics, most commonly employed to delineate the infarcted tissue from penumbra (at-risk tissue) in ischemic strokes. But abnormal CTP is also seen in stroke mimics such as seizures, hypoglycemia, tumors, migraines and PRES. In this article we describe a case of PRES in an elderly bone marrow transplant recipient who presented with focal neurological deficits concerning for a cerebrovascular accident. CTP played a pivotal role in the diagnosis and initiation of appropriate management. We also briefly discuss the pathophysiology of PRES.

Cross-sectional survey of malaria prevalence in tsunami-affected districts of Aceh Province, Indonesia

David Muriuki — 2012-02-21T00:00:00Z

Background: Malaria is endemic to Indonesia. However, there are few prevalence data available from Aceh Province because of the long-standing separatist conflict and decentralization of the public health system. The Mentor Initiative, which specializes in malaria control in humanitarian emergencies, was one of the non-governmental organizations to respond to the 2004 Indian Ocean tsunami in Aceh. Data on malaria prevalence were gathered to guide and evaluate programmatic efforts.FindingsThe Mentor Initiative conducted community-based malaria prevalence surveys in 2005 and 2006 in five districts along the tsunami-affected western coastline. A total of 11,763 individuals in 3,771 households were tested. The overall slide positivity rate in 2005 and 2006 for all Plasmodium species was 2.1% (n = 252, 95% CI 1.9%-2.4%). Slide positivity rates ranged from 0 to 55% among villages. Overall, 57% of the 252 cases were infected with P. falciparum (n = 144, 95% CI 51.0%-63.3%), and 40.1% were infected with P. vivax (n = 101, 95% CI 34.0%-46.1%), with 0.03% (n = 7, 95% CI 0.8%-4.8%) being mixed infections. Males were significantly more likely to be affected than females (2.8% vs 1.5%, p < 0.01). Infection was more common in those over the age of 5 (2.3% vs. 0.6%, p < 0.01). Conclusions: Local prevalence data are needed to design effective community-based malaria control programs, as endemicity varies greatly within districts. Certain villages were found to be hyperendemic, with slide positivity rates far higher than average in Indonesia. There is a need for ongoing malaria surveillance in Aceh Province to monitor prevention and treatment efforts.

Communicating carotid-cavernous sinus fistula following minor head trauma

Joshua Kaplan — 2012-02-13T00:00:00Z

IntroductionA case of communicating carotid-cavernous sinus fistula (CCF) after minor closed head injury is presented.Case presentationA 45-year-old Caucasian male presented to the emergency department of a tertiary care hospital with the chief complaint of blurred vision and facial numbness. The patient had experienced a minor head injury 1 month ago with loss of consciousness. After a 2-week symptom-free period, he developed scalp and facial numbness, along with headache and vision problems. His vital signs were within normal limits, but on examination the patient was noted to have orbital and carotid bruits with several concerning neurological findings. CT and MRI confirmed the suspicion of carotid-cavernous sinus fistula, which was managed by cerebral angiography with coil embolization of this fistula. The patient was symptom free at the 8-month follow-up.DiscussionCarotid-cavernous sinus fistula is a rare condition that is usually caused by blunt or penetrating trauma to the head, but can develop spontaneously in about one fourth of patients with CCF. The connection between the carotid artery and cavernous sinus leads to increased pressure in the cavernous sinus and compression of its contents, and thereby produces the clinical symptoms and signs seen. Diagnosis depends on clinical examination and neuroimaging techniques. The aim of management is to reduce the pressure within the cavernous sinus, which results in gradual resolution of symptoms.